APRIL 2004 |
Dr Ngaire Elwood - Murdoch Children's Research Institute: $65 715. Further research on original grants. A result could be the ability to use cord blood for larger children and adults.
Dr Rosemary Sparrow - Australian Red Cross Blood Service: $65 030. Study to seek the thawing process of cord blood to improve the quality of recovered frozen cord blood. |
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APRIL 2005 |
Dr Ngaire Elwood - Murdoch Children's Institute: $65 000. To further research into
improving cord blood transplantation, and the correlation between DNA length and cell growth. |
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MAY 2005 |
Associate Professor Richard D'Andrea - Women and Children's Hospital, Adelaide, SA: $65 000. This research has two aims - the first which may allow cord blood to become a safe and reliable resource for adult stem cell transplantation when a suitable bone marrow donor cannot be found. The second involves manipulating cord blood stem cells to form a special population of immune regulatory cells (T-reg cells). |
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NOVEMBER 2005 |
Professor Kerry Atkinson, Mater Medical Research Institute, Brisbane, Qld:
$65 000. Project Title - Co-transplantation of umbilical cord blood cells with human mesenchymal stem cells in order to accelerate platelet and neutrophil recovery post-transplant. |
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APRIL 2006 |
Dr Ngaire Elwood - Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Vic: $65 000. Project Title - Strategies based on telomere biology to predict successful cord blood transplant outcome. |
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APRIL 2007 |
Associate Professor Simon Barry - Child Health Research Institute Women's and Children's Hospital, North Adelaide, SA: $57 000
Project Title: Differentiation of Cord Blood Stem Cells into Regulatory T Cells for Cell Therapy.
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MAY 2007 |
Prof Kerry Atkinson, Mater Adult Hospital, Brisbane, Qld: $65 000
Project Title - Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease occurring after Unrelated Cord Blood Transplantation by Infusion of Human Mesenchymal Stem Cells. |
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MARCH 2008 |
Associate Professor Simon Barry - Child Health Research Institute, Women's and Children's Hospital, North Adelaide, SA: $61 094. To develop the clinical application of cord blood stem cells which, when cultured to increase their numbers and change them to specialised white blood cells, may be capable of preventing auto immune diseases such as type 1 diabetes, or facilitating transplants without chemical immunosuppression. |
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APRIL 2008 |
Dr Faten Zaibak and Prof Robert Williamson, Department of Pathology, University of Melbourne, Parkville, Vic: $59 089. To support research seeking to extend the use of cord blood to treat genetic diseases, specifically investigating if cord blood-derived stem cells can be used to treat cystic fibrosis. |
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Associate Professor Simon Barry et al - Women's and Children's Research Institute, Women and Children's Hospital, Adelaide: $63 016. Aims to develop clinical application of rare stem cells found in cord blood, to find if cord blood stem cells can be expanded and differentiated into Regulatory T cells ex vivo, to be in sufficient numbers for clinical intervention in transportation and autoimmune disease. |
JUNE 2009 |
Dr Ngaire Elwood - Director, BMDI Cord Blood Bank, Royal Children's Hospital, Melbourne: $44 280. Project aims to screen all cord blood (CB) collected and banked at the BMDI Cord Blood Bank over a one-year period (up to 800 CB units) for the presence of common chromosomal abnormalities to determine the frequency of these rearrangements in our population of banked CB. |
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Professor Kerry Atkinson et al - Mater Medical Research Institute and Mater Adults Hospital, Brisbane: $65 000. Aims to expand human cord blood haematopoietic stem cells so the number of HSC infused in cord blood transplants would markedly accelerate the rate of stem cell engraftment. |
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Dr Alla Dolnikov, Sydney Cord and Marrow Transplant Facility, Sydney Children's Hospital, Randwick, NSW: $65 000.
Widespread use of Umbilical Cord Blood is limited by reduced numbers of stem cells contained within the UCB (Umbilical Cord Blood) compared with BM (Bone Marrow). The focus of the research is to develop a successful strategy in the laboratory to expand UCB stem cells prior to transplantation and improve their engraftment. This will allow full utilisation of UCB resource for all patients in need of life saving transplant, particularly for patients in need of urgent transplants and ethnic minority groups where volunteer bone marrow are scarce.
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OCTOBER 2009 |
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Dr Michael Doran, Australian Institute of Bioengineering and Nanotechnology, Mater Medical Research Institute, Brisbane: $65 000. It is believed that the rate of cord blood HSC (haematopoietic stem cell) transplant engraftment can be enhanced through the ex vivo expansion of the stem cell population prior to transplant. However, to date expansion processes have actually resulted in the depletion of engrafting cells, thus the failure to enhance transplant outcomes. Dr Doran's aim is a novel strategy to rescue the transplant potential of cultured cord blood derived HSCs, thus enabling enhanced clinical outcomes. |
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Dr Alla Dolnikov, Cord & Marrow Transplant Laboratory, Sydney Children’s Hospital, Randwick, NSW: $65 000 per annum for two years.
Improving the outcome of cord blood transplant by preventing Graft Versus Host Disease (GVHD). GVHD remains the major barrier to patient survival following umbilical cord transplantation. |
| OCTOBER 2011 |
Dr Michael Doran, Australian Institute & Biomedical Innovation, Queensland University of Technology: $65 000 per annum for two year. Temporary Immune Support for Cord Blood Transplant Recipients. The safety of cord blood transplant could be improved through the provision of a large supportive expanded cord blood-derived cell population. |
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Associate Professor Simon Barry, Child Health Research Institute, Women’s and Children’s Hospital, North Adelaide, SA: $65,000 for one year. Cord Blood Stem cell derived regulatory T cells: Ex vivo expansion and characterisation for cell therapy to cure auto immune disease. |
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